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Publications
CD200
FcgRIIa
CD200
Gorczynski R, Chen Z, Kai Y et al. CD200 is a
ligand for all members of the CD200R family of immunoregulatory
molecules. J. Immunol. 2004; 172:7744.
Gorczynski R, Chen Z, Clark DA et al. Structural
and functional heterogeneity in the CD200R family of immunoregulatory
molecules and their expression at the feto-maternal interface.
Am. J. Reprod. Immunol. 2004; 52:147.
Gorczynski R, Chen Z, Kai Y et al. Induction of
tolerance-inducing antigen presenting cells in bone marrow cultures
in virto using monoclonal antibodies to CD200R. Transplantation
2004; 77:1138.
Clark DA, Keil A, Chen Z et al. Placental trophoblast
from successful human pregnancies expresses the tolerance signaling
molecule CD200 (OX-2). Am. J. Reprod. Immunol. 2003; 50:187.
Gorczynski RM, Chen Z, Lee L et al. Anti-CD200R
ameliorates collagen-induced arthritis in mice. Clin Immunol.
2002;104(3):256-264.
Gorczynski RM, Hadidi S, Yu G, Clark DA. The same
immunoregulatory molecules contribute to successful pregnancy
and transplantation. Am J Reprod Immunol. 2002;48(1):18-26.
Gorczynski RM, Hu J, Chen Z et al. A CD200FC immunoadhesin
prolongs rat islet xenograft survival in mice. Transplantation.
2002;73(12):1948-1953.
Clark DA, Yu G, Levy GA, Gorczynski RM. Procoagulants
in fetus rejection: the role of the OX-2 (CD200) tolerance signal.
Semin Immunol. 2001;13(4):255-263.
Gorczynski R, Bransom J, Cattral M et al. Dendritic
cells expressing TGFbeta/IL-10, and CHO cells with OX-2, increase
graft survival. Transplant Proc. 2001;33(1-2):1565-1566.
Gorczynski RM, Chen Z, Hu J et al. Evidence of
a role for CD200 in regulation of immune rejection of leukaemic
tumour cells in C57BL/6 mice. Clin Exp Immunol. 2001;126(2):220-229.
Gorczynski RM, Chen Z, Yu K, Hu J. CD200 immunoadhesin
suppresses collagen-induced arthritis in mice. Clin Immunol.
2001;101(3):328-334.
Gorczynski RM, Yu G, Clark D. Does successful
allopregnancy mimic transplantation tolerance? Graft 2001:4(5):338-345.
Gorczynski RM. Evidence for an immunoregulatory
role of OX2 with its counter ligand (OX2L) in the regulation
of transplant rejection, fetal loss, autoimmunity and tumor growth.
Arch Immunol Ther Exp (Warsz ). 2001;49(4):303-309.
Gorczynski RM. Role of cytokines in allograft
rejection. Curr Pharm Des. 2001;7(11):1039-1057.
Gorczynski RM. Transplant tolerance modifying
antibody to CD200 receptor, but not CD200, alters cytokine production
profile from stimulated macrophages. Eur J Immunol. 2001;31(8):2331-2337.
Gershon AS, Margulies M, Gorczynski RM, Heathcote
EJ. Serum cytokine values and fatigue in chronic hepatitis C
infection. J Viral Hepat. 2000;7(6):397-402.
Gorczynski RM, Bransom J, Cattral M et al. Synergy
in induction of increased renal allograft survival after portal
vein infusion of dendritic cells transduced to express TGFbeta
and IL-10, along with administration of CHO cells expressing
the regulatory molecule OX-2. Clin Immunol. 2000;95(3):182-189.
Gorczynski RM, Chen Z, Kai Y, Lei J. Evidence
for persistent expression of OX2 as a necessary component of
prolonged renal allograft survival following portal vein immunization.
Clin Immunol. 2000;97(1):69-78.
Gorczynski RM, Yu K, Clark D. Receptor engagement
on cells expressing a ligand for the tolerance-inducing molecule
OX2 induces an immunoregulatory population that inhibits alloreactivity
in vitro and in vivo. J Immunol. 2000;165(9):4854-4860.
Gorczynski L, Chen Z, Hu J et al. Evidence that
an OX-2-positive cell can inhibit the stimulation of type 1 cytokine
production by bone marrow-derived B7-1 (and B7-2)-positive dendritic
cells. J Immunol. 1999;162(2):774-781.
Gorczynski RM, Cattral MS, Chen Z et al. An immunoadhesin
incorporating the molecule OX-2 is a potent immunosuppressant
that prolongs allo- and xenograft survival. J Immunol. 1999;163(3):1654-1660.
Gorczynski RM, Ni J, Lei J. An immunoadhesin incorporating
the OX-2 molecule regulates mucosal cell cytokine production,
rat small intestine graft survival, and renal xenograft survival.
J Immunol. 1999 Aug 1;163(3):1654-60.
Gorczynski RM, Cohen Z, Fu XM, Lei J. Anti-rat
OX-2 blocks increased small intestinal transplant survival after
portal vein immunization. Transplant Proc. 1999;31(1-2):577-578.
Ragheb R, Abrahams S, Beecroft R et al. Preparation
and functional properties of monoclonal antibodies to human,
mouse and rat OX-2. Immunol Lett. 1999;68(2-3):311-315.
Ramakrishna V, Hu J, Lei J et al. Alterations
in chemokine mRNA expression in animals receiving portal vein
immunization and renal allo- or xenotransplantation precede altered
cytokine production. J Surg Res. 1999;87(1):62-72.
Gorczynski RM, Chen Z, Fu XM, Zeng H. Increased
expression of the novel molecule OX-2 is involved in prolongation
of murine renal allograft survival. Transplantation. 1998;65(8):1106-1114.
Chen Z, Zeng H, Gorczynski RM. Cloning and characterization
of the murine homologue of the rat/human MRC OX-2 gene. Biochim
Biophys Acta. 1997;1362(1):6-10.
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FcgRIIa
Sardjono C, Mottram P, van de Velde,
N et al. Development of spontaneous multisystem autoimmune
disease and hypersensitivity to antibody-induced inflammation
in Fcg receptor IIa-transgenic
mice. Arthritis Rheum. 2005; 52:3220.
Sardjono C, Mottram P, and Hogarth P. The role of FcgammaRIIa
as an inflammatory mediator in rheumatoid arthritis and systemic
lupus erythematosus. Immunol. Cell Biol. 2003; 81:374.
Hogarth P. Fc receptors are major mediators of antibody based
inflammation in autoimmunity. Curr. Opinion Immunol. 2002; 14:798
Maxwell K, Powell S, Hulett M et al.
Crystal structure of the human leukocyte Fc receptor, FcgRIIa.
Nature Struct. Biol. 1999; 6:437.
Hulett M, Witort E, Brinkworth R et
al. Multiple regions of human FcgRII (CD32) contribute
to the binding of IgG. J. Biol. Chem. 1995; 270:21188.
Ierino F, Powell M, McKenzie I, and
Hogarth P. Recombinant soluble human FcgRII: production,
characterization, and inhibition of the arthus reaction. J.
Exp. Med. 1993; 178:1617.
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